Heung-Mo Yang, PhD, from the Department of Surgery at Samsung, has conducted extensive research on wound healing in human skin transplanted onto nude mice. This study focuses on understanding how wound contraction occurs rapidly in the cutaneous layer of mice and explores mechanical methods to deliberately expose wounds for proper investigation. The findings provide valuable insights into healing by secondary intention.
Prostate Cancer Research: A Closer Look
The combination of androgen ablation, early detection, and surgery has significantly improved prostate cancer treatment outcomes. However, despite these advancements, prostate cancer remains the second leading cause of cancer-related deaths among American men. Researchers like Byung Joo Lee, Esther Yang, Jin Hyoung Kim, Jeong Hun Kim, and Young Suk Yu have contributed to developing orthotopic transplantation models in nude mice to study retinoblastoma. Their work aims to uncover potential treatments targeting specific cancer cells.
Athymic nude mouse models are widely used in medical research to study conditions such as hind limb ischemia and myocardial infarction. For instance, Cho HJ, Kim HS, Lee MM, Kim DH, Yang HJ, Hur J, et al., have explored mobilized endothelial cell therapy as an innovative strategy to repair damaged myocardium and promote neovascularization in ischemic border zones. These studies highlight the importance of stem cell sources in treating complex cardiovascular diseases.
Tumor Elimination in Nude Mice
Innovative approaches to eliminating established tumors in nu/nu nude mice have been developed using tumor necrosis factors. Researchers such as Yang, J Kim, JH Sohn, H Kim, CO Yun, have published their findings in Human Gene Therapy (2003). Their work on replicative strategies demonstrates promising results in combating tumor growth effectively.
Joong-Sun Kim, Juhwan Kim, Yujin Kim, Miyoung Yang, Hyosun Jang, and Sungwoon have investigated the effects of dendrotoxin-κ on suppressing tumor growth induced by human lung adenocarcinoma A549 cells in nude mice. Their study provides critical data regarding tumor suppression mechanisms and potential therapeutic applications.
Sequencing p53 Mutation in Nude Mice
Sequencing studies of p53 mutations in established human hepatocellular carcinoma cell lines (HHC4 and HHC15) in nude mice have been conducted by researchers including Yang SM, Zhou H, Chen RC, Wang YF, Chen F, Zhang CG, Zhen Y. These investigations aim to understand genetic alterations contributing to cancer progression and identify potential drug targets.
Antioxidant Capacity and Nucleotide Precursor Studies
Yang X's research on upregulating antioxidant capacity and nucleotide precursors reveals defective glycine import mechanisms. This study, co-authored with Kim H and Rabinowitz J, sheds light on metabolic pathways involved in cellular processes and their implications for human health.
Mice Models in Molecular Biology
Nude and immunocompetent mice serve as essential tools in molecular biology research. Xiuying Chen, Lin Cheng, Xuemei Jia, Yi Chi-Hung Huang, Wen-Hao Yang, Shyue-Yih Chang, Shyh-Kuan Tai, and Muh-Hwa have utilized these models to explore various biological phenomena, including vascular endothelial growth and tumor development.
Kimberly Yang's Online Presence
Beyond scientific research, personalities like Kimberly Yang, also known as Sexythangyang, have gained attention through platforms like OnlyFans. While her content primarily revolves around adult entertainment, it is important to approach such material critically and responsibly. Discussions surrounding her work often emphasize ethical considerations and digital privacy concerns.
For those interested in Kimberly Yang's exclusive content, official Telegram channels offer free previews and daily updates. Subscribers enjoy benefits such as biweekly solo videos and monthly custom-made content. However, users should ensure they comply with legal guidelines when accessing or sharing such materials.
Optical Monitoring of Tumors Using OCT
A groundbreaking method for optical monitoring of tumors in animal models involves using optical coherence tomography (OCT). Researchers cultivated PC-3 cancer cells and inoculated them into the hypodermis of auricle tissues in BALB/c nude mice. High-resolution OCT images captured tumor formation and growth patterns, providing detailed insights into tissue attenuation rates associated with tumor progression.
On the fifth day post-inoculation, histological analysis confirmed correlations between cross-sectional slices, dye-stained specimens, and OCT images. Such advancements enhance our ability to visualize and analyze tumor dynamics accurately.
Cerenkov Luminescence Imaging
Zhenhua Hu, Weidong Yang, and colleagues have employed Cerenkov luminescence imaging to study HT1080 fibrosarcoma tumors in nude mice. This technique utilizes medical isotopes to visualize tumor characteristics non-invasively, offering new possibilities for diagnostic and therapeutic interventions.
Eun Jung Choi, Eun Jin Seo, Dae Kyoung Kim, Su In Lee, Yang Woo Kwon, Il Ho Jang, Ki-Hyung Kim, Dong-Soo Suh, and Jae Ho Kim have demonstrated that knockdown of FOXP1 expression significantly reduces tumor size in nude mice. Their work underscores the significance of targeted gene therapies in oncology.
Previous studies by Kim WH, Yang H, Bang YJ, and Jeoung DI identified and characterized cancer/testis antigen CAGE's role in responding to anti-cancer drugs. Findings revealed increased cyclinD1 and pGSK3βSer9 expressions alongside decreased phospho-cyclinD1Thr286 levels, suggesting potential applications in personalized medicine.
As research continues to evolve, collaboration across disciplines will remain crucial in advancing our understanding of complex biological systems and developing effective treatments for various diseases.
